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Denon Shampoo & Soap

Denon Shampoo & Soap
Denon Shampoo & Soap
Product Code : 19
Brand Name : ZEE LABORATORIES
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Product Description
DENON Shampoo

COMPOSITION


The active ingredient is Ketoconazole 1% (i.e. 10 mg of ketoconazole per 1 g of shampoo). It also contains a conditioner for normal hair.  


ACTION
DENON Ketoconazole) is a synthetic imidazole dioxolane derivative. It works by interfering with the development of fungal cell membranes. DENON has an effect on the yeast known as Pityrosporum ovale (P.ovale) (Malassezia ovalis) which is considered to be the root cause of with dandruff. There is no evidence of systemic absorption of ketoconazole as a result of unrestricted or extended use of DENON.

 It has minimal or no irritation on the scalp and provides long lasted relief by  eliminating the root cause of dandruff.

 INDICATIONS
DENON is a medicine used for the prevention and treatment of dandruff caused by fungal infections of the scalp, as well as for the relief of associated symptoms such as flaking, scaling and itching.

CONTRA-INDICATIONS
Known hypersensitivity to ketoconazole or any of the other ingredients which may be recognised by severe itching and red-skin after application of the shampoo.

WARNINGS
As with other shampoos, avoid contact in the eyes. If this happens, however, rinse the eyes with water. If a severe rash or irritation appear after application, stop using the shampoo.

DOSAGE AND DIRECTIONS FOR USE
Wet hair and scalp. Apply sufficient shampoo to produce a generous lather. Gently massage over the entire scalp for one to three minutes to soak in before rinsing.  Use regularly, at least twice a week for 8 weeks to treat the infection. To prevent the infection reappearing, use once a week or once every two weeks.
SIDE-EFFECTS AND SPECIAL PRECAUTIONS
A local burning sensation, itching, contact dermatitis (due to irritation or allergy) or oily hair may occur on exposed areas. Although ketoconazole is not absorbed through the skin, the use of DENON is not recommended during pregnancy, as safety in pregnancy and lactation has not been established.

KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT
Not expected since DENON is intended for external use only. In the event of accidental ingestion, only supportive measures should be carried out. To avoid aspiration, neither emesis nor gastric lavage should be performed

DENON Soap

(Medicated Soap)

COMPOSITION

The active ingredient is Ketoconazole 1% (i.e. 10 mg of ketoconazole per 1 g of soap).

MECHANISM OF ACTION

 Ketoconazole interferes with the fungal synthesis of ergosterol, a constituent of cell membranes, as well as certain enzymes. It is specific for fungi, as the equivalent mammalian pathway, leading to the biosynthesis of cholesterol, is not sensitive to ketoconazole. However, other mammalian cytochrome P450 enzymes can be sensitive to ketoconazole, and inhibition of steroid hormone synthesis is a possible side effect of ketoconazole treatment. As with all azole antifungal agents, ketoconazole works principally by inhibition of an enzyme, cytochrome P450 14-alpha-demethylase (P45014DM). This enzyme is in the sterol biosynthesis pathway that leads from lanosterol to ergosterol. Fluconazole and itraconazole have been found to have a greater affinity for fungal cell membrane than ketoconazole, and thus lower doses of these azoles are required to kill fungi.

INDICATIONS

DENON Soap provides relief from itching skin folds of inner thighs, waist, buttocks, underside of breast & armpits due to sweat retention, warmth, humidity, friction & simultaneous growth of resident organism. If applied on head it is used for the prevention and treatment of dandruff caused by fungal infections of the scalp, as well as for the relief of associated symptoms such as flaking, scaling and itching.

CONTRA-INDICATIONS

 Known hypersensitivity to ketoconazole or any of the other ingredients which may be recognised by severe itching and red-skin after application of the soap

WARNINGS

As with other soap, avoid contact in the eyes. If this happens, however, rinse the eyes with water. If a severe rash or irritation appear after application, stop using the soap. DIRECTIONS FOR USE Wet the body and rub gently to produce lather, leave it for 3 to 5 minutes and then rinse thoroughly. Use regularly to prevent occurrences.

SIDE-EFFECTS AND SPECIAL PRECAUTIONS

A local burning sensation, itching, contact dermatitis (due to irritation or allergy) may occur. Although ketoconazole is not absorbed through the skin, the use of DENON is not recommended during pregnancy, as safety in pregnancy and lactation has not been established.

KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT

 Not expected since DENON is intended for external use only. In the event of accidental ingestion, only supportive measures should be carried out. To avoid aspiration, neither emesis nor gastric lavage should be performed.

IDENTIFICATION : An opaque blue to blue-green colour cake with a slight perfume odour.

PRESENTATION : 75 gm. Soap sealed in Aluminium/poly bag, Packed in a carton.

A Product From ZEE LABORATORIES LTD.

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